The dry granulation process is usually used When the mixture works or operates as expected when exposed to moisture and heat. The main difference in this process is that the liquid is never introduced into the mixture. After mixing the prepared ingredients, the powder will be fed into a machine that will apply tremendous pressure and force to make the powder tighter and increase the bulk density. The required force depends on the mixture, composition, and density.

The packaging process

Manufacturing nutritional capsules is a process that requires many steps to achieve perfection. When producing these capsules, materials must be collected. After preparing all the materials, they are combined with hot demineralized water and mixed in the machine by vacuum. Over time, if needed, more hot water, dye, and sunscreen will be added to the mixture. When prepared, the mixture will be molded around a steel needle into a capsule of the correct size and shape. Then dry both ends of the capsule together. The temperature and humidity levels are monitored to achieve optimal drying of the capsules correctly. After preparing and drying the capsule, the lid and body will be trimmed. The capsules are put together, ready to be filled, and sent. Using animal skins such as pig and cattle double-layer skin to make medicinal capsules has been practically used. The method uses acid-base and low heat to degrade the collagen in animal skins into gelatin protein, extract gelatin, and then dissolve and glue the gelatin to shape it. Dry and solidify. The collagen in animal skin is directly used to prepare collagen, and then the medicinal capsule is made through modeling and other treatments. There is no report or actual use so far. Use animal skins to make collagen, then make edible collagen casings.

Gelatin extraction process

The treatment process is complicated, the raw materials are used low, and the three wastes are discharged. In the process of gelatin molding and drying to make capsules, the requirements for temperature, humidity, colloidal concentration, and gelatin quality indicators such as viscosity, freezing power, fluidity, etc. are strict. A lot of equipment is needed. Because the molecular weight of gelatin protein is small, it has great cohesiveness in water or moisture absorption and has poor heat resistance. Gelatin capsules have inconveniences in making, using, eating, and storing. Gelatin capsules have low strength and high brittleness and require more raw materials for production. There are inconveniences in production and storage. It needs to be treated with a fixative to reduce water solubility and increase water solubility. The residual fixative has a certain effect on the human body—adverse effects. Using collagen to make capsules can reduce the processing steps, discharge three wastes, and have long collagen fibers. The prepared capsules have high dry strength, good toughness, and less breakage. They require less materials and dissolve in water and acid, so the production process is unnecessary. Or use less fixative. Since collagen has stronger self-adhesiveness than gelatin, the colloid with the same solid content has high collagen strength, low fluidity, good rigidity, and low bonding strength, which has obvious advantages in manufacturing. The mold can be coated with a large amount of release agent for easy demolding, and it can be directly sprayed on the mold to form, dry, and perform other treatments. Instead of making gelatin capsules like gelatin capsules, the gelatin colloid is glued on the mold. The film is sprayed to form the film, which is easy to coat the film uniformly, and the coating thickness is accurate. The appearance and other dimensions of the finished product are easy to control. Because the amount of collagen used is small, the deviation of the thickness of the capsule wall caused by the deviation of the concentration during modeling is small, which is beneficial to the dimensional accuracy of the finished product. The production of collagen capsules is made by coating and drying collagen. The colloid’s temperature, viscosity, environmental temperature, and humidity are small during the production process. The medicinal capsule made of animal skin collagen can replace the medicinal capsule made of gelatin, and its usage and medicinal value are the same as gelatin capsules.